Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression
نویسندگان
چکیده
منابع مشابه
Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression.
BACKGROUND Mitochondrial dysfunction plays an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). We aimed to demonstrate mitochondrial dysfunction in ALS using a lactate stress test and to examine the relationship between mitochondrial dysfunction with motor deterioration. METHODS We enrolled 116 patients and observed clinical variables, including the survival state. ...
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ALS is a devastating neurodegenerative disorder with no effective treatment. In the present study, we found that daily doses of lithium, leading to plasma levels ranging from 0.4 to 0.8 mEq/liter, delay disease progression in human patients affected by ALS. None of the patients treated with lithium died during the 15 months of the follow-up, and disease progression was markedly attenuated when ...
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ژورنال
عنوان ژورنال: Chinese Medical Journal
سال: 2016
ISSN: 0366-6999
DOI: 10.4103/0366-6999.172561